Flying squirrel-associated Rickettsia prowazekii (epidemic typhus rickettsiae) characterized by a specific DNA fragment produced by restriction endonuclease digestion.
نویسندگان
چکیده
The DNA from flying squirrel-associated Rickettsia prowazekii was characterized by using a specific DNA fragment produced by digestion with the enzyme BamHI. The DNA fragment was cloned into a plasmid vector and used to readily distinguish between available human- and flying squirrel-associated R. prowazekii DNAs derived from crude cytoplasmic extracts.
منابع مشابه
Genome Sequencing of Four Strains of Rickettsia prowazekii, the Causative Agent of Epidemic Typhus, Including One Flying Squirrel Isolate
Rickettsia prowazekii is a notable intracellular pathogen, the agent of epidemic typhus, and a potential biothreat agent. We present here whole-genome sequence data for four strains of R. prowazekii, including one from a flying squirrel.
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T fever from Rickettsia prowazekii infection is a severe and occasionally fatal disease in humans. Frequently referred to as epidemic typhus or louse-borne typhus, this disease can cause large epidemics when conditions are favorable for person-to-person spread of body lice (Pediculus humanus humanus). For the last few decades, reported outbreaks have been confined mainly to the cold mountainous...
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Rickettsia prowazekii, the causative agent of epidemic typhus, is an obligate intracellular bacterium that replicates only within the cytosol of a eukaryotic host cell. Despite the barriers to genetic manipulation that such a life style creates, rickettsial mutants have been generated by transposon insertion as well as by homologous recombination mechanisms. However, progress is hampered by the...
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The genus Rickettsia includes the causative agents of some of the most historically significant and severe bacterial diseases of humans. These include Rickettsia prowazekii, the agent responsible for epidemic typhus, and R. rickettsii, the agent of Rocky Mountain spotted fever. Additional species, including R. typhi, responsible for murine or endemic typhus, and others, responsible for a variet...
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 23 1 شماره
صفحات -
تاریخ انتشار 1986